May 11, 2020

Covid-19: a non-linear and systemic tale over the past and the future of this crazy epidemic

I'm reading and writing many stuff about, during this epidemic and if I don't know it so well is just because I hadn't the "chance" to meet it directly but I guess I'm happy anyway of this miss encounter!
I tried to imagine the story of this epidemic and their so many facets of the fact, not in direct biological terms related to the virus genome, but as a travel of our "visitor": this SARS CoV-2.
So here my tale!

The story as I imagine

I can just make some hypothesis or just some fun on the true story of the virus or better of the viruses: in those days we were so used to speak about VIRUS that we all (virologists included) start to think to virus as it is a huge ball with a sort of strange ambulacral pedicels that are just able to grasp on a human cellular membrane to open a way to itself to enter and wreck out that cellule and the host's body at a whole.
I know no one virologist think that way but the way they communicate to the folk produces this result!

As I said in a previous post over a strange way to imagine a possible general immunization we can imagine that the dangerous virus could start being just the one that in a past sad morning of October or November (someone says that was maybe December or September, the dawn it's not perfectly clear) found itself out of a cellule (impossible to say if it was human or batman cellule) with a strange desire: "mommy I want to be diverse!" ("mommy" is the cellule that hosted the replication of the previous virus-stamp!). As the weather outside was turning toward a cold Fall or Winter our JohnCV Sr (CV stays for CoronaVirus: this is the name - seems to be - of our vHero) decided to stay very warm in the buffers of some animal/human, giving back to its new host a little bit of hitch in the bronchia and meanwhile never forgetting to multiply itself as much as it could as its ancestors were usual, together with its brothers and sisters (it is not clear if we can think about them as male of female!) cousins and afar relatives: those who gave just a little bit of disturb to the host, maybe just a stupid sneezing. 
They therefore became some hundreds with the same desire: to hitch the host bronchia! 
... and the bronchia reacted: the host coughed!
... and after a short fly in open sky - some here and some others there and there and there - they landed hundreds on a new host! 
It was a mess: a bunch of cousins, relatives and unknown afar kinfolks flew together all with their own specializations: sneezing, coughing, do-nothing, alerting, catch-me-soon and so on! So a new adventure was coming, a new unknown host was reached!

As in every group of individuals there is a sort of emulation and defy, sooner or later among the many flying and consequent hosts reached and coughing, there was again a virus JamesCV Sr - coming from the same strain of our first vHero, JohnCV Sr - who again was tired of that stupid game: just making the host coughing finally was boring! 
And all those stupid third-to-n-power cousins that just produce some fever or sneeze! That was what was done for centuries ("centuries" in terms of virus time and life!) by its parents, grand parents and ancestors for generations and generations - not to speak about stupid sneezers and similar - so: "enough with it! I have to invent something new! I've seen that my uncle and my cousins here have produced more hitch than what I've ever seen by others and that is the reason why we were projected more afar than any other cousin we have! Geeee! Sneezers (viruses sneezers) also can be effective, they project a lot of us around!!! So let join our forces let have strong cough and some powerful sneezes in order to fly around!

But now the hosts are trying to get rid of us using drugs, vapors and other remedia! Better to learn how to stay more quiet than others as are the sneezers!" 
So for some generations those viruses tried to remain calm and concealed for longer than usual, with the passion anyway for hitching the host until he/she finally: few coughs, short flies and new hosts and unknown bronchia! Yeeha! Disguised yet powerful!!!

The new generation, a vampire story!

So that game played for long - concealed yet alive and invading - was going to take a turn! Bored again for having done what ancestors and parents have done for so long and distilled in some hosts to be distanced from the stupid just sneezers, once again one new vHero GlimpherCV Sr (some hundreds of generations have passed meanwhile and now it is the great, great,...., great grandson of the previous one JamesCV Sr and the name style was changed also, but Sr and/or Jr still remain: tradition!!!) decides to change the rules of the game: "Now I want to dig more and instead of just hitching the bronchia I would like to thinker with those nice oily balls (epithelial cellules of vacuole and their blood vessels) a little bit deeper in the buffers and then tickle them on the surface and maybe entering that membrane (cellular membrane) leaving my capsyd on the surface to be recognizable (a sort of graffito) by those damn lymphocytes, just to see how they react: do they either hit me or stupidly they hit my host cellule!
Meanwhile I leave all my brother to continue with the bronchia up there, they do not know other job than what they have done so far, no innovation, no challenge, no future!!!
I know Lymphocytes are stupid enough to kill the host cellule but for me its's sufficient to leave before, just to go around with my new sons to spread their future breeds.
I'm more amused in disturbing that stupid host more than hitching the bronchia; to succed in it I enjoy the chance of traveling with my stupid cousins that still are amusing themselves with that boring hitching to the bronchia. Anyway, if I need to be projected around, me and my breed, I'll happily accept a ride with their group: when they make the cough happen I will fly with them! Meanwhile some of my breed will stay here to thinker with membranes and those stupid Lymphocytes!

What's going on?

Having learned how to stay quiet for a while my breed has become really prolific and they learned how to take a lazy pace toward the vacuoles. Their laziness had no any relationship with the damage they did and still do to the host they are dwelling, but I'm proud of them by the fact that they are projected around only after they become numerous, more numerous than choughers.

As much the hitch becomes strong - doesn't matter what breed is producing it: I just scoffed at them because they are different than "us" but it's not said, we all cooperate to that! - as much the spread increases its efficiency! Production, production production!!!

Some generation have passed meanwhile when recently a new vHero BrosGerbCV Jr had bad news about hosts coughing alone in a white room!!! (now Jr also is going to be used, but their names are becoming more and more strange, I don't know why, maybe just to sport a sort of differentiation?).  No other new and unvisited bronchia and vacuoles or lymphocytes to trigger beside or in front? It's sad, we spent so many generations to specialize ourselves that is now a pity that our evolution doesn't make us victorious and effective as it was foreseen long time ago when we started to increase our efficiency! We are now stopped here - I dare to say lockedown - with nothing to do!!! What about my breed!!! Do I have to risk extinction and to finish here my breed and my life seeing my poor children lingering here and die in a crematorium?
More bad news now, what an envy!!! Naaaahhh, don't tell me that all those stupid of our afar-kinds are going better than us (we are not racists but we cannot call them anymore cousins, we have forgotten our kinship long time ago, with that stupid hitchers and sneezers!). But how can they amuse with just hitching od sneezing with the host! They are cought immediately, lymphocytes are catching them soon and from then on, no more chances to make an easy job! Lymphocytes react soon and well aimed, not anymore on vessels and vacuoles! 

Traitors!!!

So when Glooster-the-GreatCV JrJr, the Magnificent (a sort of megalomany got them all! It didn't know yet that it was going to become a sort of general George A. Custer) discovered that things were going worse because its strain was no more able to mock of Lymphocytes and reach capillar vessels to attack them (time had passed since they were just playing/thinkering: they actually started to move a true war against hosts even though they were so gently accepted in a warm and humid place to have good reproduction rate and strong help by their marchingeni: Ribosomes, Golgi's apparatus and so on)!!! 
They are now catched very soon!!! Before they were able to defeat the host once on 5 and now the percentage of success was lowering down and down and down!!! It's a real drama: the Magnificent is astonished, it doesn't understand why now the reaction of hosts are so strong and sudden! WHO (without any implication with the human meaning of it even if involved!!!) is the guilty!!!
Aren't they maybe - those stupid pre-JohnCV Sr cousins' breeds from our far ancestors - becoming traitors and, warning our all possible hosts around with a pityful and puny war, they teach them how to fight and easily defeat us too? Us!!! The breed of the Magnificent!!!
How do our hosts call it? Immunization? What a hell of word!!! it only annoys me to hear that spoken!
I'm really upset!!! That risks to evenctually become our end!!! That means that soon only some sneezing and coughing will fly around by the cause of our "... cousins...", no more chances for us - the fighters - no more mortal wars!!!
Is that the END of JohnCV Sr's better and stronger lineage!!!

Moral of the story?

All epidemics in our history have finished because the dangerous strains were segregated with quarantine; thus only weak strains could go around the environment and the hosts, making weaker attacks so spreading immunization instead!

Only the arrogance of low quality scholars - that I don't dare to name scientists because they don't understand they are acting in a non deterministic system, as the life is - can treat the life as a mechanicistic strucuture where you can push button of an immaginary vaccine and it produces the results as foreseen. They have the claim to control one by one all viruses going around our Earth and Media and to be able to defeat the disease produced by a well know highly varying Coronavirus.

But - worse than that - they will try to get the merit and honors of the defeat of this epidemic even if it will normally arrive alone to an end, as life and evolution in themselves forever have produced (or conserved) the seeds for the following needed immunity! Didn't Cowpox virus acted that way Vs Smallpox!

... and what about the greed of those who look for absolute power and/or the billionnaire Jackpot of being the Emperor of World's Health?

JohnCV Sr would be happy to know to have gained so great reputation and importance up to trigger important decisions in the world economy just because of the scare it has produced!

That is just a tale!!!


(© Luca CODELUPPI)

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